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June 2016

Volume 2  Issue 1

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Research Article

I.V. Levetiracetam versus Phenobarbitone in Neonatal Seizures A Randomized, Single Blind Prospective Clinical Trial

Adel A. H. Mahmoud FRCP, MRCPCH, Ayman Tagelsir Abdalla SSC Ped, SF Neo, Ahmed M. A. Elajab MD, MRCPCH, Ahmed A. Mansy MSc, M.D

Seizures in neonates are relatively common. Only few studies are available about the safety and efficacy of  antiepileptic drugs used for treatment of neonatal seizures. The standard treatment has been Phenobarbitone (PB). Usually it is given as intravenous (I.V.) and followed when it is successful, by the oral form. Recently Levetiracetam (LEV) was studied with promising results. Here we compare the safety and efficacy of LEV with PB in the treatment of neonatal seizures.    

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Original Article

Clinical Investigation of Kawasaki Disease in Patients aged Five years or Older at Onset

Eiichi Yamamoto, MD, Takashi Higaki, MD*, Takeshi Nakano, MD, Ryusuke Watanabe, MD, Kyoko Konishi, MD, Yoshihiro Takahashi, MD, Yasushi Ishida, MD, Eiichi Ishii, MD

Kawasaki disease (KD), first reported 47 years ago, is a vasculitis of still unknown etiology. Approximately 10,000 patients are diagnosed with KD every year in Japan, and this number is gradually increasing. The disease most commonly develops during infancy and early childhood (up to 4 years old), and its incidence peaks around 1 year. The most debilitating feature is the development or persistence of coronary artery damage during the acute phase. Coronary artery dilation or coronary aneurysm developed in approximately 10% of these patients.     

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Case Report

A Mild Presentation of Immune Dysregulation Polyendocrinopathy Enteropathy X-linked Syndrome

Collette Spalding MD, Julie Khlevner MD, Minsoo Kim MD*

Patients with Immune Dysregulation Polyendocrinopathy Enteropathy X-linked Syndrome classically present in infancy with intractable diarrhea, chronic dermatitis and autoimmune disorders. However, its presentation can be variable and often very mild. We present an atypically mild case of IPEX demonstrating the importance of genetic workup and high index of suspicion. Laboratory evaluation was performed including T, B, and NK cells, immunoglobulin levels, autoantibodies, lymphocyte mitogen proliferation assay, as well as neutrophil oxidative burst assay. FOXP3 flow cytometry was performed on peripheral blood mononuclear cells and the FOXP3 gene was sequenced.     

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